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Serum creatinine supplanted BUN for the assessment of kidney function in the mid-1900s and remains the most widely used laboratory test to estimate GFR 19

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Higher levels of glutathione may help protect against gestational diabetes and preeclampsia by regulating two hormones related to insulin sensitivity: adiponectin and plasminogen activator inhibitor

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Targeting oxidative stress in central nervous system disorders

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However, systemic copper loading remains a theoretical concern requiring careful dose optimization and copper status monitoring, particularly with chronic administration protocols

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